fixation



fixation defined in 1951 year

fixation - fixation;
fixation - The first step in making permanent preparations of organisms or tissues for microscopic study; aims at killing cells, i.e. preventing subsequent change through metabolism or decay, with the least distortion of structure and in such a way that subsequent study is as easy as possible. Various chemicals are used as fixatives (e.g. formaldehyde, osmium tetroxide), often as mixtures. Almost all produce some artefacts, by aggregation of proteins or by dissolving structures.

near fixation in Knolik


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